This Outpost was named U for obvious reasons. While it is very rare I have seen Brain eat through a block from the outside resource gatherers to the outpost although this is usually only if the attack is over anyhow. In each blocked area there are buildings for both resource targeting and tower targeting monsters. While the design is simple it will take any type of monster time to get around to everything in this yard.
At the time that I was creating these screen shots from the game I did not have the traps laid out. There are various areas in this base these could be placed. On the outside of each "U" is a great place because all types of monsters will go around these corners at some point during the attack. Optionally you could place some around the Outpost building itself as those corners are also likely to be hit during the attack.
This outpost is at elevation and has a 5% tower range boost although the guns are far from maximum level. Snipers and Cannons are all level 5, Tesla and ADT are level 3, Lasers are level 5, Railgun is level 6.
Below is an example attack of Teratorn against this outpost. Science hasn't prevailed so far.